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Cached July 10 2003
Cyanocobalamin (Vitamin B12)
Cyanocobalamin (Kaybovite-1000, Redisol)
Vitamin B12 (Kaybovite-1000, Redisol)
Pregnancy Category: A (C in doses that exceed the RDA) Nasal gel: Ener-B Nascobal (OTC) (Rx)
Pregnancy Category: C Crystamine Crysti 1000 Cyanoject Cyomin Rubesol-1000 (OTC) (Rx)
Classification: Vitamin B12
Action/Kinetics: Required for hematopoiesis, cell reproduction, nucleoprotein
and myelin synthesis. Plasma vitamin B12 levels: 150-750 pg/mL. Rapidly
absorbed following IM or SC administration. Following absorption, vitamin
B12 is carried by plasma proteins to the liver where it is stored until
required for various metabolic functions. t1/2: 6 days (400 days in the
liver). Time to peak levels, after PO: 8-12 hr.
Uses: Cyanocobalamin Gel/Tablets: Nutritional vitamin B12 deficiency;
not to be used for treatment of pernicious anemia. Cyanocobalamin Parenteral:
Vitamin B12 deficiency due to malabsorption syndrome as seen in pernicious
anemia. GI pathology, dysfunction, or surgery. Fish tapeworm infestation,
maligancy of pancreas or bowel, gluten enteropathy, small bowel overgrowth
of bacteria, sprue, accompanying folic acid deficiency, or total or partial
Contraindications: Hypersensitivity to cobalt, Leber's disease.
Special Concerns: Use with caution in clients with gout.
Side Effects: Following parenteral use. Allergic: Urticaria, itching,
transitory exanthema, anaphylaxis, shock, death. CV: Peripheral vascular
thrombosis CHF, pulmonary edema. Other: Polycythemia vera, optic nerve
atrophy in clients with hereditary optic nerve atrophy, diarrhea, hypokalemia,
body feels swollen.
NOTE: Benzyl alcohol, which is present in certain products, may cause a fatal ``gasping syndrome'' in premature infants.
Laboratory Test Alterations: Antibiotics, methotrexate, or pyrimethamine
invalidate folic acid and vitamin B12 diagnostic blood assays.
Drug Interactions: Alcohol / Vitamin B12 absorption Aminosalicylic
acid / Vitamin B12 effect. Also, abnormal Schilling test and symptoms
of vitamin B12 deficiency Chloramphenicol / Response to vitamin B12
in pernicious anemia Cholestyramine / Vitamin B12 absorption Cimetidine
/ Digestion and release of vitamin B12 Colchicine / Vitamin
B12 absorption Neomycin / Vitamin B12 absorptionPAS / Vitamin
B12 absorption Potassium, timed-release / Vitamin B12 absorption
How Supplied: Cyanocobalamin: Gel: 400 mcg/unit, 500 mcg/0.1 mL; Tablet:
25 mcg, 50 mcg, 100 mcg, 250 mcg; Cyanocobalamin crystalline: Injection:100
mcg/mL, 1,000 mcg/mL; Tablets; 500 mcg, 1000 mcg